The high metabolic rate required for tumor growth often leads to hypoxia in poorly-perfused
regions. Hypoxia activates a complex gene expression program, mediated by hypoxia …

▪ Abstract Computational models of the electrical and mechanical function of the heart are
reviewed. These models attempt to explain the integrated function of the heart in terms of …

A fundamental variable in culture medium is its pH, which must be controlled by an
appropriately formulated buffering regime, since biological processes are exquisitely …

1 Intracellular pH was recorded fluorimetrically by using carboxy‐SNARF‐1, AM‐loaded into
superfused ventricular myocytes isolated from guinea‐pig heart. Intracellular acid and base …

CA9 is a membrane-tethered, carbonic anhydrase (CA) enzyme, expressed mainly at the
external surface of cells, that catalyzes reversible CO 2 hydration. Expression is greatly …

Acidosis of the tumor microenvironment leads to cancer invasion, progression and
resistance to therapies. We present a biophysical model that describes how tumor cells …

Aims Technological limitations have restricted in vivo assessment of intracellular pH (pHi) in
the myocardium. The aim of this study was to evaluate the potential of hyperpolarized [1 …

pH is a fundamental physiological parameter that is tightly controlled by endogenous
buffers. The acid–base balance is altered in many disease states, such as inflammation …

Background and purpose: Intracellular pH (pHi) in heart is regulated by sarcolemmal H+‐
equivalent transporters such as Na+‐H+ exchange (NHE) and Na+‐HCO3− cotransport …

Substrate depletion and increased intracellular acidity are believed to underlie clinically
important manifestations of myocardial ischmia. Recent advances in measuring ion …