Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Neuronal nicotinic acetylcholine receptors comprise a heterogeneous class of cationic
channels that is present throughout the nervous system. These channels are involved both …
channels that is present throughout the nervous system. These channels are involved both …
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations
AA Jensen, B Frølund, T Liljefors… - Journal of medicinal …, 2005 - ACS Publications
The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …
Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia
JW Young, SB Powell, V Risbrough, HM Marston… - Pharmacology & …, 2009 - Elsevier
Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …
with functional outcome, and are not well treated with current antipsychotic therapies. In …
Smoking, nicotine and neuropsychiatric disorders
P Dome, J Lazary, MP Kalapos, Z Rihmer - Neuroscience & Biobehavioral …, 2010 - Elsevier
Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption,
but unfortunately also the most prevalent. Although disproportionately high frequencies of …
but unfortunately also the most prevalent. Although disproportionately high frequencies of …
Smoking and suicide: a brief overview
JR Hughes - Drug and alcohol dependence, 2008 - Elsevier
This article provides a brief overview of the rationales, possible mechanisms and
epidemiological data on the association of smoking, smoking cessation and cessation …
epidemiological data on the association of smoking, smoking cessation and cessation …
[HTML][HTML] Distributed network actions by nicotine increase the threshold for spike-timing-dependent plasticity in prefrontal cortex
Nicotine enhances attention and working memory by activating nicotinic acetylcholine
receptors (nAChRs). The prefrontal cortex (PFC) is critical for these cognitive functions and …
receptors (nAChRs). The prefrontal cortex (PFC) is critical for these cognitive functions and …
Brain neuronal nicotinic receptors as new targets for drug discovery
C Gotti, L Riganti, S Vailati… - Current pharmaceutical …, 2006 - ingentaconnect.com
Neuronal nicotinic receptors (nAChRs) are a heterogeneous family of ion channels
differently expressed in the nervous system where, by responding to the endogenous …
differently expressed in the nervous system where, by responding to the endogenous …
Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia
The group of schizophrenia disorders affects approximately 1% of the population and has
both genetic and environmental etiologies. Sufferers report various behavioral abnormalities …
both genetic and environmental etiologies. Sufferers report various behavioral abnormalities …
Central nicotinic receptors: structure, function, ligands, and therapeutic potential
MN Romanelli, P Gratteri, L Guandalini… - ChemMedChem …, 2007 - Wiley Online Library
The growing interest in nicotinic receptors, because of their wide expression in neuronal and
non‐neuronal tissues and their involvement in several important CNS pathologies, has …
non‐neuronal tissues and their involvement in several important CNS pathologies, has …
Nicotine self‐medication of cognitive‐attentional processing
DE Evans, DJ Drobes - Addiction biology, 2009 - Wiley Online Library
This article selectively reviews research concerning nicotine's effects on cognition, including
the neurobiological mechanism for these effects, task and experimental features that may be …
the neurobiological mechanism for these effects, task and experimental features that may be …