Various strategies can be employed to prevent and manage altitude illnesses, including
habituation, oxygenation, nutritional support, and medication. Nevertheless, the utilization of …

Immune outcomes are key mediators of many health benefits of exercise and are
determined by exercise type, dose (frequency/duration, intensity), and individual …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At
high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain …

Objectives Hypoxia is a physiological state characterized by reduced oxygen levels in
organs and tissues. It is a common clinicopathological process and a major cause of health …

Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out
of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely …

Aim Under hypobaric hypoxia (HH), the heart triggers various defense mechanisms
including metabolic remodeling against lack of oxygen. Mitofusin 2 (MFN2), located at the …

Reduced oxygen availability (hypoxia) can lead to cell and organ damage. Therefore,
aerobic species depend on efficient mechanisms to counteract detrimental consequences of …

Supplemental oxygen (hyperoxia) improves physical performance during hypoxic exercise.
Based on the analysis of metabolome and iron homeostasis from human athlete blood …

Objective The high-altitude hypoxia environment will cause poor acclimatization in a portion
of the population. Remote ischemic preconditioning (RIPC) has been demonstrated to …