While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

There are few in vitro models of exocrine pancreas development and primary human
pancreatic adenocarcinoma (PDAC). We establish three-dimensional culture conditions to …

Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove
harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution …

Aerobic glycolysis (the Warburg effect) has been demonstrated to facilitate tumor
progression by producing lactate, which has important roles as a proinflammatory and …