Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023 - thelancet.com
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

Epidemiology of epilepsy and seizures

Z Chen, MJ Brodie, D Ding, P Kwan - Frontiers in epidemiology, 2023 - frontiersin.org
Epilepsy is a chronic neurological disorder characterised by recurrent unprovoked seizures.
1 It affects an estimated 50 million people worldwide with no socio-demographic boundary …

Real‐world safety and effectiveness of cenobamate in patients with focal onset seizures: outcomes from an expanded access program

V Villanueva, D Santos‐Carrasco… - Epilepsia …, 2023 - Wiley Online Library
Objective This study investigated early, real‐world outcomes with cenobamate (CNB) in a
large series of patients with highly drug‐resistant epilepsy within a Spanish Expanded …

Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy

LM Willems, M Hochbaum, K Frey, J Schulz… - …, 2022 - Wiley Online Library
Objective This study was undertaken to quantify epilepsy‐related costs of illness (COI) in
Germany and identify cost‐driving factors. Methods COI were calculated among adults with …

Neuromorphic deep spiking neural networks for seizure detection

Y Yang, JK Eshraghian, ND Truong… - Neuromorphic …, 2023 - iopscience.iop.org
The vast majority of studies that process and analyze neural signals are conducted on cloud
computing resources, which is often necessary for the demanding requirements of deep …

Preferences and user experiences of wearable devices in epilepsy: a systematic review and mixed-methods synthesis

S Sivathamboo, D Nhu, L Piccenna, A Yang… - Neurology, 2022 - AAN Enterprises
Background and Objectives To examine the preferences and user experiences of people
with epilepsy and caregivers regarding automated wearable seizure detection devices …

Productivity-adjusted life-years: a new metric for quantifying disease burden

Z Ademi, IN Ackerman, E Zomer, D Liew - Pharmacoeconomics, 2021 - Springer
For many years, disability-adjusted life-years have been a primary focus of the landmark
Global Burden of Disease studies [1]. Incorporating years of life lost and years of life lived …

Trends in resource utilization and cost of illness in patients with active epilepsy in Germany from 2003 to 2020

LM Willems, M Hochbaum, JP Zöllner, J Schulz… - …, 2022 - Wiley Online Library
Objective This study was undertaken to calculate epilepsy‐related direct, indirect, and total
costs in adult patients with active epilepsy (ongoing unprovoked seizures) in Germany and …

Missed, mistaken, stalled: identifying components of delay to diagnosis in epilepsy

N Alessi, P Perucca, AM McIntosh - Epilepsia, 2021 - Wiley Online Library
A substantial proportion of individuals with newly diagnosed epilepsy report prior seizures,
suggesting a missed opportunity for early epilepsy care and management. Consideration of …

A multimodal AI system for out-of-distribution generalization of seizure identification

Y Yang, ND Truong, JK Eshraghian… - IEEE Journal of …, 2022 - ieeexplore.ieee.org
Artificial intelligence (AI) and health sensory data-fusion hold the potential to automate many
laborious and time-consuming processes in hospitals or ambulatory settings, eg home …