The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC)
transporter family is one of the most widely recognized mechanisms of multidrug resistance …

Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic
diseases,,,–. However, the molecular and cellular mechanisms that mediate the metabolic …

During the fermentation of soy sauce, the metabolism of microorganisms and the Maillard
reaction produce a wide variety of metabolites that contribute to the unique and rich flavor …

Mitochondrial disorders represent a large collection of rare syndromes that are difficult to
manage both because we do not fully understand biochemical pathogenesis and because …

Background: Blood chemicals are routinely measured in clinical or preclinical research
studies to diagnose diseases, assess risks in epidemiological research, or use metabolomic …

The absorption, distribution and excretion of drugs are largely determined by their
transporters (DTs), the variability of which has thus attracted considerable attention. There …

Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce
blood glucose levels and suppress appetite. Here we report a significant elevation of the …

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight.
There is ongoing debate about the mechanisms that mediate metformin's effects on energy …

Context Diabetic retinopathy (DR) is a specific microvascular complication in patients with
diabetes and the leading cause of blindness. Recent advances in omics, especially …

Individuals can exhibit differences in metabolism that are caused by the interplay of genetic
background, nutritional input, microbiota and other environmental factors,,–. It is difficult to …