Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

ATP-binding cassette transporter A1 (ABCA1) is an integral cell-membrane protein that
mediates the rate-limiting step of high density lipoprotein (HDL) biogenesis and suppression …

Insulin resistance is a critical pathophysiological process in the onset and advancement of
type 2 diabetes mellitus. It is well-recognized that alterations in the metabolism of lipids and …

Low-grade chronic inflammation plays a pivotal role in the pathogenesis of insulin
resistance (IR), and skeletal muscle has a central role in this condition. NLRP3 …

Insulin resistance onset in skeletal muscle is characterized by the impairment of insulin
signaling, which reduces the internalization of glucose, known as glucose uptake, into the …

Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of
morbidity and mortality worldwide. COPD rarely occurs in isolation and is often combined …

Background Skeletal muscle generates force and movements and maintains posture. Under
pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation …

Sphingolipids and cholesterol are two lipid partners on cellular membranes where they form
specific microdomains, named lipid rafts, which mediate specific cell functions …

Elevated glucocorticoids alter the skeletal muscle transcriptome to induce a myopathy
characterized by muscle atrophy, muscle weakness, and decreased metabolic function …

Abstract Background: microRNAs (miRNAs) post-transcriptionally regulate gene expression
and act as important modulators of cholesterol homeostasis. Objectives: The study explores …