Sequencing of transposon insertion libraries is used to determine the relative fitness of
individual mutants at a large scale. However, there is a lack of tools for specifically analyzing …

The Pragmatic Insertional Mutation Mapping (PIMMS) laboratory protocol was developed
alongside various bioinformatics packages to enable detection of essential and conditionally …

Motivation: Current methods for visualising and interrogating high-throughput transposon
insertion mutagenesis sequencing (TIS) data requires a significant time investment in …

Identification of essential genes is key to understanding the required processes and gene
products of organisms under one or more conditions. Transposon sequencing (Tn-seq) has …

Streptococcus (S.) suis is a commensal porcine pathogen that is the leading causative agent
of bacterial meningitis and sepsis in young pigs globally. Systemic infection in swine is …

Grâce aux progrès de la synthèse et de l'assemblage d'ADN, il est maintenant possible de
créer des génomes complètement différents de ceux retrouvés dans la nature. Il sera bientôt …

Staphylococcus aureus is a gram positive coccoid pathogen that causes intractable
infections in hospitals and communities around the world, and tens of thousands of people …