Next-generation sequencing for confronting virus pandemics

J Quer, S Colomer-Castell, C Campos, C Andrés… - Viruses, 2022 - mdpi.com
Virus pandemics have happened, are happening and will happen again. In recent decades,
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

Q Chen, C Perales, ME Soria, D García-Cehic… - Antiviral Research, 2020 - Elsevier
A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-
based treatment regimens, often because of drug resistance-associated substitutions (RAS) …

Safety and efficacy of combined sofosbuvir/daclatasvir treatment of children and adolescents with chronic hepatitis C genotype 4

TY Abdel Ghaffar, S El Naghi… - Journal of viral …, 2019 - Wiley Online Library
Direct‐acting antivirals have become available for treating chronic HCV (hepatitis C virus)
infection in adults and, recently, in children at least 12 years old. Our aim was to investigate …

Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus

ME Soria, J Gregori, Q Chen, D García-Cehic… - BMC Infectious …, 2018 - Springer
Background Despite the high sustained virological response rates achieved with current
directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of …

Full-genome next-generation sequencing of hepatitis C virus to assess the accuracy of genotyping by the commercial assay LiPA and the prevalence of resistance …

KT Christensen, F Pierard, K Beuselinck… - Journal of Clinical …, 2022 - Elsevier
Background Although most currently used regimens for Hepatitis C virus (HCV) infections
can be initiated without prior knowledge of genotype and subtype, genotyping is still useful …

Evaluation of 8‐week glecaprevir/pibrentasvir treatment in direct‐acting antiviral‐naïve noncirrhotic HCV genotype 1 and 2infected patients in a real‐world setting in …

H Ikeda, T Watanabe, M Atsukawa… - Journal of Viral …, 2019 - Wiley Online Library
Based on high efficacy and safety demonstrated in clinical trials, treatment with glecaprevir/
pibrentasvir (G/P) for 8 weeks is recommended for hepatitis C virus (HCV)–infected patients …

A novel standardized deep sequencing-based assay for hepatitis C virus genotype determination

C Rodriguez, A Soulier, V Demontant, L Poiteau… - Scientific Reports, 2018 - nature.com
Hepatitis C virus (HCV) genotype and subtype (1a/1b) identification is needed to tailor anti-
HCV therapy. Currently available methods accurately identify the genotype and differentiate …

The EIMB hydrogel microarray technology: thirty years later

DA Gryadunov, BL Shaskolskiy… - Acta Naturae …, 2018 - cyberleninka.ru
Biological microarrays (biochips) are analytical tools that can be used to implement complex
integrative genomic and proteomic approaches to the solution of problems of personalized …

Reliable resolution of ambiguous hepatitis C virus genotype 1 results with the Abbott HCV Genotype Plus RUO assay

V Saludes, A Antuori, B Reinhardt, I Viciana… - Scientific reports, 2019 - nature.com
Accurate subtyping of hepatitis C virus genotype 1 (HCV-1) remains clinically and
epidemiologically relevant. The Abbott HCV Genotype Plus RUO (GT Plus) assay, targeting …

Whole-genome characterization and resistance-associated substitutions in a new HCV genotype 1 subtype

G Von Massow, D Garcia-Cehic, J Gregori… - Infection and drug …, 2019 - Taylor & Francis
Hepatitis C virus (HCV) is a highly variable infectious agent, classified into 8 genotypes and
86 subtypes. Our laboratory has implemented an in-house developed high-resolution HCV …