Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives
D He, M Wang, S Zhao, Y Shu, H Zeng, C Xiao, C Lu… - Fitoterapia, 2017 - Elsevier
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted
increasing interest because of their broad spectrum of biological functions. This review …
increasing interest because of their broad spectrum of biological functions. This review …
[HTML][HTML] Quinazolinones, the winning horse in drug discovery
AM Alsibaee, HM Al-Yousef, HS Al-Salem - Molecules, 2023 - mdpi.com
Quinazolines are nitrogen-containing heterocycles that consist of a benzene ring fused with
a pyrimidine ring. Quinazolinones, oxidized quinazolines, are promising compounds with a …
a pyrimidine ring. Quinazolinones, oxidized quinazolines, are promising compounds with a …
Synthesis, characterization and molecular docking studies of highly selective new hydrazone derivatives of anthranilic acid and their ring closure analogue Quinazolin …
In this study, new Schiff bases derived from anthranilic acid hydrazide (3a-j) and quinazolin-
4 (3H)-one (4a-j) were synthesized with high yields (99-90%) and characterized by FTIR …
4 (3H)-one (4a-j) were synthesized with high yields (99-90%) and characterized by FTIR …
Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity
In the current research, methaqualone derivatives were synthesized and assessed for their
anti-convulsant activity. Among them, compounds 3, 4, 6, 7 and 11 exhibited significant anti …
anti-convulsant activity. Among them, compounds 3, 4, 6, 7 and 11 exhibited significant anti …
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4 (3H)-quinazolinones
AM Alaa, LA Abou-Zeid, KEH ElTahir, RR Ayyad… - European Journal of …, 2016 - Elsevier
A new series of 2-substituted mercapto-4 (3H)-quinazolinone 1–26 were synthesized and
assessed for in vivo anti-inflammatory and analgesic activities and in vitro inhibition of …
assessed for in vivo anti-inflammatory and analgesic activities and in vitro inhibition of …
Synthesis and antitumor evaluation of trimethoxyanilides based on 4 (3H)-quinazolinone scaffolds
MA Mohamed, RR Ayyad, TZ Shawer, AM Alaa… - European journal of …, 2016 - Elsevier
Abstract A novel series of 2-[(3-substituted-4 (3H)-quinazolin-2-yl) thio]-N-(3, 4, 5-
trimethoxyphenyl) acetamide (15–21) and 3-[(3-substituted-4 (3H)-quinazolin-2-yl) thio])-N …
trimethoxyphenyl) acetamide (15–21) and 3-[(3-substituted-4 (3H)-quinazolin-2-yl) thio])-N …
Synthesis, cytotoxic evaluation, and molecular docking studies of novel quinazoline derivatives with benzenesulfonamide and anilide tails: Dual inhibitors of EGFR …
We synthesized a new series of 2-[(3-(4-sulfamoylphenethyl)-4 (3H)-quinazolinon-2-yl) thio]
anilide derivatives (2–16) and evaluated their cytotoxic activity against breast …
anilide derivatives (2–16) and evaluated their cytotoxic activity against breast …
Pyrazolo [3, 4-d] pyrimidine-based dual EGFR T790M/HER2 inhibitors: design, synthesis, structure–activity relationship and biological activity as potential antitumor …
PF Lamie, AM El-Kalaawy, NSA Latif… - European Journal of …, 2021 - Elsevier
A new series of pyrazolo [3, 4-d] pyrimidine/triazine hybrids 6a-r was designed as antitumor
and anticonvulsant agents. All the prepared compounds were evaluated against colon (HCT …
and anticonvulsant agents. All the prepared compounds were evaluated against colon (HCT …
Design, synthesis of 2, 3-disubstitued 4 (3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking …
AM Alaa, LA Abou-Zeid, KEH ElTahir… - Bioorganic & Medicinal …, 2016 - Elsevier
A new series, 2-substituted mercapto-3-[2-(pyridin-2-yl) ethyl]-4 (3H)-quinazolinone 1–21,
was synthesized and evaluated for in vivo anti-inflammatory and analgesic activities and in …
was synthesized and evaluated for in vivo anti-inflammatory and analgesic activities and in …
C(sp2)–H Functionalization of 2H-Indazoles at C3-Position via Palladium(II)-Catalyzed Isocyanide Insertion Strategy Leading to Diverse Heterocycles
S Vidyacharan, A Murugan… - The Journal of Organic …, 2016 - ACS Publications
Herein, we have reported an efficient Pd-catalyzed C–H functionalization of 2 H-indazole at
C3-position via an isocyanide insertion strategy for the synthesis of unprecedented …
C3-position via an isocyanide insertion strategy for the synthesis of unprecedented …