Why not try harder? Computational approach to motivation deficits in neuro-psychiatric diseases

M Pessiglione, F Vinckier, S Bouret, J Daunizeau… - Brain, 2018 - academic.oup.com
Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric
diseases. Even when they are not the core symptom, they reduce quality of life, compromise …

Clinical predictors of therapeutic response to antipsychotics in schizophrenia

M Carbon, CU Correll - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
The search for clinical outcome predictors for schizophrenia is as old as the field of
psychiatry. However, despite a wealth of large, longitudinal studies into prognostic factors …

EPA guidance on assessment of negative symptoms in schizophrenia

S Galderisi, A Mucci, S Dollfus, M Nordentoft… - European …, 2021 - cambridge.org
BackgroundDuring the last decades, a renewed interest for negative symptoms (NS) was
brought about by the increased awareness that they interfere severely with real-life …

The current conceptualization of negative symptoms in schizophrenia

SR Marder, S Galderisi - World Psychiatry, 2017 - Wiley Online Library
Negative symptoms have long been conceptualized as a core aspect of schizophrenia. They
play a key role in the functional outcome of the disorder, and their management represents a …

Second‐generation antipsychotic effect on cognition in patients with schizophrenia—a meta‐analysis of randomized clinical trials

RE Nielsen, S Levander… - Acta Psychiatrica …, 2015 - Wiley Online Library
Objective To investigate the effect of second‐generation antipsychotics on cognitive function
in patients diagnosed with schizophrenia or schizoaffective disorder. Method Multiple …

Thinking and acting beyond the positive: the role of the cognitive and negative symptoms in schizophrenia

M Carbon, CU Correll - CNS spectrums, 2014 - cambridge.org
Since currently available antipsychotic medications predominantly treat hallucinations,
delusions, disorganized thoughts and behavior, and related agitation/aggression, attention …

Pathophysiology of negative symptom dimensions of schizophrenia–current developments and implications for treatment

I Bègue, S Kaiser, M Kirschner - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Negative symptoms of schizophrenia comprise a group of severe symptoms contributing to
high disease burden and poor long-term prognosis. Conceptual work has shown that these …

Motivational deficits in early schizophrenia: prevalent, persistent, and key determinants of functional outcome

G Fervaha, G Foussias, O Agid, G Remington - Schizophrenia research, 2015 - Elsevier
Negative symptoms, in particular motivational deficits, are reported as impediments to
functional recovery in patients with schizophrenia. This study examined the prevalence of …

The efficacy of cariprazine in negative symptoms of schizophrenia: Post hoc analyses of PANSS individual items and PANSS-derived factors

W Fleischhacker, S Galderisi, I Laszlovszky… - European …, 2019 - cambridge.org
Background: Negative symptoms in schizophrenia are heterogeneous and
multidimensional; effective treatments are lacking. Cariprazine, a dopamine D3-preferring …

[PDF][PDF] Standards für die Behandlung im Maßregelvollzug nach §§ 63 und 64 StGB.

J Müller, N Saimeh, P Briken, S Eucker… - Der …, 2017 - researchgate.net
Die Behandlung in den Kliniken für Forensische Psychiatrie und Psychotherapie und den
forensisch psychiatrischen Ambulanzen ist Teil des Versorgungsangebots für psychisch …