Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases.
This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Photoacoustic imaging (PAI), a novel imaging modality based on photoacoustic effect,
shows great promise in biomedical applications. By converting pulsed laser excitation into …

Carboxylesterase (CE) is crucial in metabolizing ester-containing biomolecules and is
particularly significant in liver metabolic diseases. Herein, we present the first activatable …

The majority of diseases' biomarkers are enzymes, and the regulation of enzymes is
fundamental but crucial. Biological system disorders and diseases can result from abnormal …

Carboxylesterases (CEs) are widely distributed in the body and catalyze the hydrolysis of
endogenous and exogenous substrates. They play important roles in drug metabolism, and …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of
mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated …