Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …

Depression is an overwhelming health concern, and many patients fail to optimally respond
to available standard therapies. Neuroplasticity and blood–brain barrier (BBB) integrity are …

Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABA A subunit-
containing GABA A receptors (δGABA A Rs) that respond to ambient GABA levels and …

We assessed the antidepressant-like effects of environmental enrichment (EE) and physical
exercise (PE) compared with the selective serotonin reuptake inhibitor fluoxetine against the …

Anxiety disorders constitute a spectrum of psychological conditions affecting millions of
individuals worldwide, imposing a significant health burden. Historically, the development of …

Perceived racial discrimination (PRD) has been documented as a risk factor for worse
psychological well-being among African Americans. Yet, most researchers have not …

Mounting evidence shows that physical activity, social interaction and sensorimotor
stimulation provided by environmental enrichment (EE) exert several neurobehavioural …

The sucrose preference test is a popular test for anhedonia in the chronic unpredictable
stress model of depression. Yet, the test does not always produce consistent results. Long …

This review describes the role of social isolation in the development of anxiety and
depression-like behavior in rodents. The duration of social isolation, age from onset of social …