Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy

L Yang, A Li, Y Wang, Y Zhang - Signal transduction and targeted …, 2023 - nature.com
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

[HTML][HTML] Microbial therapeutic enzymes: A promising area of biopharmaceuticals

M Vachher, A Sen, R Kapila, A Nigam - Current Research in Biotechnology, 2021 - Elsevier
Biopharmaceuticals is a rapidly emerging field that explores and employs biological
organisms and their products for therapeutic applications. Enzymes are remarkable …

A critical review on exploitation of agro-industrial biomass as substrates for the therapeutic microbial enzymes production and implemented protein purification …

D Raina, V Kumar, S Saran - Chemosphere, 2022 - Elsevier
Annually, a huge amount of waste is generated by the industries that use agricultural
biomass. Researchers have looked into employing this cheap and renewable agro-biomass …

[HTML][HTML] The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions

Y Fu, J Li, W Cai, Y Huang, X Liu, Z Ma, Z Tang… - … Pharmaceutica Sinica B, 2024 - Elsevier
Intratumoral microbiota has become research hotspots, and emerges as a non-negligent
new component of tumor microenvironments (TME), due to its powerful influence on tumor …

Lysinated multiwalled carbon nanotubes with carbohydrate ligands as an effective nanocarrier for targeted doxorubicin delivery to breast cancer cells

CK Thakur, R Neupane, C Karthikeyan, CR Ashby Jr… - Molecules, 2022 - mdpi.com
Multiwalled carbon nanotubes (MWCNTs) are elongated, hollow cylindrical nanotubes
made of sp2 carbon. MWCNTs have attracted significant attention in the area of drug …

Microbial L-asparaginase as a promising enzyme for treatment of various cancers

F Darvishi, Z Jahanafrooz, A Mokhtarzadeh - Applied Microbiology and …, 2022 - Springer
Metabolic differences between normal and cancerous cells have been used as a point of
view for developing anticancer drugs. Some degrading enzymes of certain amino acids …

PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression

Q Zhou, L Li, F Sha, Y Lei, X Tian, L Chen, Y Chen… - Cancer Research, 2023 - AACR
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a
poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC …

Arginine deprivation as a strategy for cancer therapy: An insight into drug design and drug combination

Y Zhang, SF Chung, SY Tam, YC Leung, X Guan - Cancer Letters, 2021 - Elsevier
Extensive studies have shown that cancer cells have specific nutrient auxotrophy and thus
have much a higher demand for certain nutrients than normal cells. Amino acid deprivation …

Amino acid degrading enzymes and autophagy in cancer therapy

Z Wang, Q Xie, H Zhou, M Zhang, J Shen… - Frontiers in …, 2021 - frontiersin.org
Recently, there has been renewed interest in metabolic therapy for cancer, particularly in
amino acid deprivation by enzymes. L-asparaginase was approved for the treatment of …

Biomedical applications of microbial phenylalanine ammonia lyase: Current status and future prospects

A Kawatra, R Dhankhar, A Mohanty, P Gulati - Biochimie, 2020 - Elsevier
Phenylalanine ammonia lyase (PAL) has recently emerged as an important therapeutic
enzyme with several biomedical applications. The enzyme catabolizes l-phenylalanine to …