Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
L Yang, A Li, Y Wang, Y Zhang - Signal transduction and targeted …, 2023 - nature.com
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …
human health. An altered microbiome can be associated with complex diseases …
[HTML][HTML] Microbial therapeutic enzymes: A promising area of biopharmaceuticals
Biopharmaceuticals is a rapidly emerging field that explores and employs biological
organisms and their products for therapeutic applications. Enzymes are remarkable …
organisms and their products for therapeutic applications. Enzymes are remarkable …
A critical review on exploitation of agro-industrial biomass as substrates for the therapeutic microbial enzymes production and implemented protein purification …
D Raina, V Kumar, S Saran - Chemosphere, 2022 - Elsevier
Annually, a huge amount of waste is generated by the industries that use agricultural
biomass. Researchers have looked into employing this cheap and renewable agro-biomass …
biomass. Researchers have looked into employing this cheap and renewable agro-biomass …
[HTML][HTML] The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions
Y Fu, J Li, W Cai, Y Huang, X Liu, Z Ma, Z Tang… - … Pharmaceutica Sinica B, 2024 - Elsevier
Intratumoral microbiota has become research hotspots, and emerges as a non-negligent
new component of tumor microenvironments (TME), due to its powerful influence on tumor …
new component of tumor microenvironments (TME), due to its powerful influence on tumor …
Lysinated multiwalled carbon nanotubes with carbohydrate ligands as an effective nanocarrier for targeted doxorubicin delivery to breast cancer cells
Multiwalled carbon nanotubes (MWCNTs) are elongated, hollow cylindrical nanotubes
made of sp2 carbon. MWCNTs have attracted significant attention in the area of drug …
made of sp2 carbon. MWCNTs have attracted significant attention in the area of drug …
Microbial L-asparaginase as a promising enzyme for treatment of various cancers
Metabolic differences between normal and cancerous cells have been used as a point of
view for developing anticancer drugs. Some degrading enzymes of certain amino acids …
view for developing anticancer drugs. Some degrading enzymes of certain amino acids …
PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression
Q Zhou, L Li, F Sha, Y Lei, X Tian, L Chen, Y Chen… - Cancer Research, 2023 - AACR
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a
poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC …
poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC …
Arginine deprivation as a strategy for cancer therapy: An insight into drug design and drug combination
Y Zhang, SF Chung, SY Tam, YC Leung, X Guan - Cancer Letters, 2021 - Elsevier
Extensive studies have shown that cancer cells have specific nutrient auxotrophy and thus
have much a higher demand for certain nutrients than normal cells. Amino acid deprivation …
have much a higher demand for certain nutrients than normal cells. Amino acid deprivation …
Amino acid degrading enzymes and autophagy in cancer therapy
Z Wang, Q Xie, H Zhou, M Zhang, J Shen… - Frontiers in …, 2021 - frontiersin.org
Recently, there has been renewed interest in metabolic therapy for cancer, particularly in
amino acid deprivation by enzymes. L-asparaginase was approved for the treatment of …
amino acid deprivation by enzymes. L-asparaginase was approved for the treatment of …
Biomedical applications of microbial phenylalanine ammonia lyase: Current status and future prospects
Phenylalanine ammonia lyase (PAL) has recently emerged as an important therapeutic
enzyme with several biomedical applications. The enzyme catabolizes l-phenylalanine to …
enzyme with several biomedical applications. The enzyme catabolizes l-phenylalanine to …