The human immune defense system routinely expresses the tumour necrosis factor (TNF)-
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …

Induction of apoptosis in cancer cells has increasingly been the focus of many therapeutic
approaches in oncology field. Since its identification as a TNF family member, TRAIL (TNF …

Simple Summary Many cancer therapeutics do not account for the complexity of the tumor
microenvironment (TME), which may result in failure when applied clinically. In this paper we …

Unmethylated cytosine-phosphorothioate-guanine (CpG)-containing oligodeoxynucleotides
(ODNs) are synthetic DNA sequences that mimic bacterial DNA, and are known to serve as …

Since its identification as a member of the tumour necrosis factor (TNF) family, TRAIL (TNF-
related apoptosis-inducing ligand) has emerged as a new avenue in apoptosis-inducing …

Background Death receptor 5 (DR5) is a promising therapeutic target for cancer therapy.
However, many clinical trials of DR5 agonists failed to show significant therapeutic efficacy …

Background Radiogenetic therapy is a novel approach in the treatment of cancer, which
employs genetic modification to alter the sensitivity of tumor cells to the effect of applied …

In the past few years, basic and clinical scientists have witnessed landmark achievements in
many research projects, such as those conducted by the US National Institutes of Health …

Gene therapy emerged as a mighty alternative for conventional treatment of multiple
diseases. It has been defined as a product “that mediate their effects by transcription and/or …

Background: Prostate cancer (PCa) is the fourth most common tumor in males. Objective:
This study aimed to investigate effects of atorvastatin (AS) on PCa cells proliferation and …