Sepsis is often complicated by an acute and reversible deterioration of mental status, which
is associated with increased mortality and is consistent with delirium but can also be …

Objective Sepsis-associated delirium is a common and poorly understood neurological
complication of sepsis. This review provides an update of the diagnostic criteria and …

Lipopolysaccharide (LPS), the principal cell-wall component of gram-negative bacteria, is
responsible for alterations in the central and peripheral tissues associated with gram …

Brain dysfunction is a severe complication of sepsis with an incidence ranging from 9% to
71% that is associated with increased morbidity and mortality. Its diagnosis relies mainly on …

Background Cerebral microhemorrhages (CMH) are tiny deposits of blood degradation
products in the brain and are pathological substrates of cerebral microbleeds. The existing …

The blood vessels that supply the inner ear form a barrier between the blood and the inner
ear fluids to control the exchange of solutes, protein, and water. This barrier, called the blood …

Peripheral inflammation can aggravate local brain inflammation and neuronal death. The
blood–brain barrier (BBB) is a key player in the event. On a relevant in vitro model of primary …

Nanoparticles targeting transporters of the blood-brain barrier (BBB) are promising
candidates to increase the brain penetration of biopharmacons. Solute carriers (SLC) are …

Aims: Although alcohol drinking impairs the blood–brain barrier (BBB), the underlying
mechanism is not fully understood. Thus, the effects of chronic ethanol drinking on the BBB …

Aggregation and cytotoxicity of misfolded α-synuclein are postulated to be crucial in the
disease processes of Parkinson's disease (PD) and other synucleinopathies. Mutations in …