Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has
been used for centuries in traditional Asian medicine, and nowadays it is widely used in food …

Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …

Oxidative stress causes various diseases, such as type II diabetes and dyslipidemia, while
antioxidants in foods may prevent a number of diseases and delay aging by exerting their …

Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …

Porcupine is a constituent of the 19 membered Wnt family with diverse biological features
such as cell differentiation, cell proliferation, cell migration, apoptosis, etc. Porcupine is a …

Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …

Colorectal‐cancer (CRC) is the third leading cause of death due to cancer, supporting the
need for identification of novel anticancer drug to improve the efficacy of current‐therapy …

Curcumin exhibits anti-tumor effects in several cancers, including colorectal carcinoma
(CRC), but the detailed mechanisms are still unclear. Here we studied the mechanisms …