Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Adenosine, a purine nucleoside generated by the dephosphorylation of adenine
nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of
the immune system which contribute to the control of microbial pathogens and tumors. There …

Although inflammatory and immunological reactions protect the host from invasion by
microorganisms and eliminate debris at sites of tissue injury, they can also be responsible …

Adenosine has been implicated in suppressing the proinflammatory responses of classically
activated macrophages induced by Th1 cytokines. Alternative macrophage activation is …

Abstract Treatment of inflammatory diseases today is largely based on interrupting the
synthesis or action of mediators that drive the host's response to injury. Non-steroidal anti …