The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although
this metabolic conversion may primarily represent a rescue pathway to meet the …

▪ Abstract Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are
beneficial in the primary and secondary prevention of coronary heart disease. However, the …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Ample evidence exists in support of the potent anti-inflammatory properties of statins. In cell
studies and animal models statins exert beneficial cardiovascular effects. By inhibiting …

Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Currently, five different statins (simvastatin, pravastatin, lovastatin, fluvastatin, and
atorvastatin) are approved for treatment of hypercholesterolemia in humans and two new …

Recent epidemiologic studies have shown that aerobic exercise, one of lifestyle
modifications, reduces cardiovascular morbidity and mortality in the general population …