There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …

Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant
and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of …

The molecular mechanisms causing the loss of dopaminergic neurons containing
neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson's …

A pathological feature of Parkinson's disease (PD) is the progressive loss of dopaminergic
neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD …

Dopaminergic neurons of the substantia nigra selectively degenerate over the course of
Parkinson's disease. These neurons are also the most heavily pigmented cells of the brain …

During aging, neuronal organelles filled with neuromelanin (a dark-brown pigment) and lipid
bodies accumulate in the brain, particularly in the substantia nigra, a region targeted in …

Purpose To investigate the physical mechanisms associated with the contrast observed in
neuromelanin MRI. Methods Phantoms having different concentrations of synthetic melanins …

Neuromelanins are compounds accumulating in neurons of human and animal brain during
aging, with neurons of substantia nigra and locus coeruleus having the highest levels of …

The mechanisms by which parkin protects the adult human brain from Parkinson disease
remain incompletely understood. We hypothesized that parkin cysteines participate in redox …

Iron is essential for neurons and glial cells, playing key roles in neurotransmitter synthesis,
energy production and myelination. In contrast, high concentrations of free iron can be …