The success of the Severe Acute Respiratory Syndrome Coronavirus 2 mRNA vaccines to
lessen/prevent severe COVID-19 opened new opportunities to develop RNA vaccines to …

SUMMARY A major impediment for HIV cure is the ability of the virus to integrate its genome
in the form of replication-competent proviral DNA into the cellular genome of the host and …

Abstract HIV-1 envelope glycoproteins (Envs) of most primary HIV-1 strains exist in closed
conformation and infrequently sample open states, limiting access to internal epitopes. Thus …

Motivation Changing the course of the human immunodeficiency virus type I (HIV-1)
pandemic is a high public health priority with approximately 39 million people currently living …

HIV-1 hijacks host proteins involved in membrane trafficking, endocytosis, and autophagy
that are critical for virus replication. Molecular details are lacking but are essential to inform …

Activated-to-memory transitioning CD4+ T cells display elevated expression of the HIV-1 co-
receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53 …

Persistent HIV-1 reservoirs of infected CD4 T cells are a major barrier to HIV-1 cure,
although the mechanisms by which they are established and maintained in vivo remain …

The envelope glycoprotein (Env) trimer on the surface of human immunodeficiency virus
type I (HIV-1) mediates viral entry into host CD4+ T cells and is the sole target of neutralizing …

Rapid detection of microbial-induced cellular changes during the course of an infection is
critical to understanding pathogenesis and immunological homeostasis. In the last two …

The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells
requires binding of the viral spike glycoprotein to the angiotensin-converting enzyme 2 …