Innovative and rapid antimicrobial susceptibility testing systems

A van Belkum, CAD Burnham, JWA Rossen… - Nature Reviews …, 2020 - nature.com
Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid
detection and quantification of resistance, combined with antimicrobial stewardship, are key …

Antimicrobial treatment and resistance in sexually transmitted bacterial infections

JS Jensen, M Unemo - Nature Reviews Microbiology, 2024 - nature.com
Sexually transmitted infections (STIs) have been part of human life since ancient times, and
their symptoms affect quality of life, and sequelae are common. Socioeconomic and …

Themisto: a scalable colored k-mer index for sensitive pseudoalignment against hundreds of thousands of bacterial genomes

JN Alanko, J Vuohtoniemi, T Mäklin, SJ Puglisi - Bioinformatics, 2023 - academic.oup.com
Motivation Huge datasets containing whole-genome sequences of bacterial strains are now
commonplace and represent a rich and important resource for modern genomic …

Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects

D Golparian, M Unemo - Expert Review of Molecular Diagnostics, 2022 - Taylor & Francis
Introduction Several nucleic acid amplification tests (NAATs), mostly PCRs, to detect
antimicrobial resistance (AMR) determinants and predict AMR in Neisseria gonorrhoeae are …

Advances in genotypic antimicrobialresistance testing: a comprehensive review

B Duan, X Zeng, J Peng - Science China Life Sciences, 2024 - Springer
Antimicrobial resistance (AMR) represents a substantial threat to global public health,
complicating the treatment of common infections and leading to prolonged illness and …

Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018

Q Yuan, Y Li, L Xiu, C Zhang, Y Fu, C Jiang… - Emerging Microbes & …, 2019 - Taylor & Francis
The growing multidrug-resistant Neisseria gonorrhoeae is a serious global threat to
gonococcal therapy. During 2017–2018, we identified a rare multidrug-resistant (ceftriaxone …

Genomic prediction of antimicrobial resistance: ready or not, here it comes!

EM Ransom, RF Potter, G Dantas… - Clinical …, 2020 - academic.oup.com
Background Next-generation sequencing (NGS) technologies are being used to predict
antimicrobial resistance. The field is evolving rapidly and transitioning out of the research …

Genomic surveillance and antimicrobial resistance in Neisseria gonorrhoeae isolates in Bangkok, Thailand in 2018

D Golparian, R Kittiyaowamarn… - Journal of …, 2022 - academic.oup.com
Objectives Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a substantial global
public health problem. Gonococcal infections acquired in or from Asia represent most …

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

SG Palace, Y Wang, DHF Rubin, MA Welsh… - Elife, 2020 - elifesciences.org
Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended
for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic …

Emergence of a Neisseria gonorrhoeae clone with reduced cephalosporin susceptibility between 2014 and 2019 in Amsterdam, The Netherlands, revealed by …

J de Korne-Elenbaas, SM Bruisten… - Journal of …, 2021 - academic.oup.com
Background Emerging resistance to cephalosporins in Neisseria gonorrhoeae (Ng) is a
major public health threat, since these are considered antibiotics of last resort. Continuous …