Engineered gene drives—the process of stimulating the biased inheritance of specific genes—
have the potential to enable the spread of desirable genes throughout wild populations or to …

Genetics can potentially provide new, species-specific, environmentally friendly methods for
mosquito control. Genetic control strategies aim either to suppress target populations or to …

There is great interest in being able to spread beneficial traits throughout wild populations in
ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element …

Engineered gene drives based on a homing mechanism could rapidly spread genetic
alterations through a population. However, such drives face a major obstacle in the form of …

Aedes mosquitoes include important vector species such as Aedes aegypti, the major vector
of dengue. Genetic control methods are being developed for several of these species …

Replacement of wild insect populations with genetically modified individuals unable to
transmit disease provides a self-perpetuating method of disease prevention but requires a …

Background CRISPR gene drive systems allow the rapid spread of a genetic construct
throughout a population. Such systems promise novel strategies for the management of …

The spread of synthetic gene drives is often discussed in the context of panmictic
populations connected by gene flow and described with simple deterministic models. Under …

Malaria, dengue, Zika and other mosquito‐borne diseases continue to pose a major global
health burden through much of the world, despite the widespread distribution of insecticide …

Replacement of wild insect populations with transgene-bearing individuals unable to
transmit disease or survive under specific environmental conditions using gene drive …