Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

The design of carriers for insulin delivery has recently attracted major research attentions in
the biomedical field. In general, the release of drug from polymers is driven via a variety of …

Cell-based therapy is emerging as a promising strategy for treating a wide range of human
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

The development of cell microencapsulation systems began several decades ago. However,
today few systems have been tested in clinical trials. For this reason, in the last years …

Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …

The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …

Pretransplant islet culture is associated with the loss of islet cell mass and insulin secretory
function. Insulin secretion from islet β-cells is primarily controlled by mitochondrial ATP …

Bone marrow mesenchymal stromal cells (BM-MSCs) have anti-inflammatory and pro-
survival properties. Naturally, they do not express human leukocyte antigen class II surface …

Islet transplantation has proved one of the most remarkable transmissions from an
experimental curiosity into a routine clinical application for the treatment of type I diabetes …