The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic …

H Kahroba, B Ramezani, H Maadi, MR Sadeghi… - Ageing research …, 2021 - Elsevier
Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system.
NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs …

Therapeutic efficacies of berberine against neurological disorders: an update of pharmacological effects and mechanisms

JW Shou, PC Shaw - Cells, 2022 - mdpi.com
Neurological disorders are ranked as the leading cause of disability and the second leading
cause of death worldwide, underscoring an urgent necessity to develop novel …

Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPARδ for antioxidant action

JW Shou, XX Li, YS Tang, BLH Kong, HY Wu… - Free Radical Biology …, 2022 - Elsevier
Cerebral ischemic stroke ranks the second leading cause of death and the third leading
cause of disability in lifetime all around the world, urgently necessitating effective therapeutic …

Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO‐1 pathway

R Zhang, B Lei, G Wu, Y Wang, Q Huang - Bioorganic chemistry, 2023 - Elsevier
Neuronal apoptosis has been found to have a pivotal role in the course of Alzheimer's
disease (AD). Berberine (BBR), a potent antioxidant, occurs in plants such as Berberis …

ASCL1-mediated ferroptosis resistance enhances the progress of castration-resistant prostate cancer to neurosecretory prostate cancer

J Nie, P Zhang, C Liang, Y Yu, X Wang - Free Radical Biology and …, 2023 - Elsevier
Neuroendocrine prostate cancer (NEPC) is a multi-resistant variant of prostate cancer (PCa)
that frequently emerges in castration-resistant prostate cancer (CRPC). NEPC is usually …

Hormesis and neural stem cells

EJ Calabrese, V Calabrese, G Dhawan… - Free Radical Biology …, 2022 - Elsevier
This paper provides a detailed identification and assessment of hormetic dose responses in
neural stem cells (NSCs) as identified in a number of animal models and human tissues …

Research progress on neuroprotective effects of isoquinoline alkaloids

J Li, Y Wu, S Dong, Y Yu, Y Wu, B Xiang, Q Li - Molecules, 2023 - mdpi.com
Neuronal injury and apoptosis are important causes of the occurrence and development of
many neurodegenerative diseases, such as cerebral ischemia, Alzheimer's disease, and …

[HTML][HTML] Estrogen genotoxicity causes preferential development of Fuchs endothelial corneal dystrophy in females

V Kumar, N Deshpande, M Parekh, R Wong, S Ashraf… - Redox Biology, 2024 - Elsevier
Fuchs endothelial corneal dystrophy (FECD) is a genetically complex, age-related, female-
predominant disorder characterized by loss of post-mitotic corneal endothelial cells …

[HTML][HTML] NFE2L1/Nrf1 serves as a potential therapeutical target for neurodegenerative diseases

K Łuczyńska, Z Zhang, T Pietras, Y Zhang, H Taniguchi - Redox Biology, 2023 - Elsevier
The failure of the proper protein turnover in the nervous system is mainly linked to a variety
of neurodegenerative disorders. Therefore, a better understanding of key protein …

Berberine reduces lipid accumulation in obesity via mediating transcriptional function of PPARδ

JW Shou, PC Shaw - International Journal of Molecular Sciences, 2023 - mdpi.com
Obesity is defined as a dampness-heat syndrome in traditional Chinese medicine. Coptidis
Rhizoma is an herb used to clear heat and eliminate dampness in obesity and its …