The goal of this review article is to assess how relevant is the concept of dissipative structure
for understanding the dynamical bases of non-equilibrium self-organization in biological …

The advances in genetics and biochemistry that have taken place over the last 10 years led
to significant advances in experimental and clinical immunology. In turn, this has led to the …

Molecular noise restricts the ability of an individual cell to resolve input signals of different
strengths and gather information about the external environment. Transmitting information …

An introduction to the mathematical concepts and techniques needed for the construction
and analysis of models in molecular systems biology. Systems techniques are integral to …

Oscillations within the cell regulate the timing of many important life cycles. However, in this
noisy environment, oscillations can be highly inaccurate owing to phase fluctuations. It …

Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an
exquisite example of how cellular signaling pathways can be regulated to produce different …

Mathematical modeling has proved to be a critically important approach in the study of many
complex networks and dynamic systems in physics, engineering, chemistry, and biology …

The control of proteins by a transcription factor with periodically varying concentration
exhibits intriguing dynamical behaviour. Even though it is accepted that transcription factors …

Infected cells communicate through secreted signaling molecules like cytokines, which carry
information about pathogens. How differences in cytokine secretion affect inflammatory …

Abstract In the 1960's Brian Goodwin published a couple of mathematical models showing
how feedback inhibition can lead to oscillations and discussed possible implications of this …