Pharmacological actions of statins: a critical appraisal in the management of cancer
P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
Protein disulfide isomerase in redox cell signaling and homeostasis
FRM Laurindo, LA Pescatore… - Free Radical Biology and …, 2012 - Elsevier
Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …
Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques
Plaque rupture followed by thrombosis is the underlying cause of the majority of acute
coronary syndromes. Circulating microparticles (cMPs), membrane blebs released into …
coronary syndromes. Circulating microparticles (cMPs), membrane blebs released into …
Update on lipids, inflammation and atherothrombosis
L Badimon, RF Storey, G Vilahur - Thrombosis and haemostasis, 2011 - thieme-connect.com
Atherosclerosis is an inflammatory disease that involves the arterial wall and is
characterised by the progressive accumulation of lipids in the vessel wall. The first step is …
characterised by the progressive accumulation of lipids in the vessel wall. The first step is …
Platelet-released extracellular vesicles: the effects of thrombin activation
Platelets exert fundamental roles in thrombosis, inflammation, and angiogenesis,
contributing to different pathologies from cardiovascular diseases to cancer. We previously …
contributing to different pathologies from cardiovascular diseases to cancer. We previously …
Effect of statins on platelet activation and function: from molecular pathways to clinical effects
A Nenna, F Nappi, M Lusini… - BioMed Research …, 2021 - Wiley Online Library
Purpose. Statins are a class of drugs widely used in clinical practice for their lipid‐lowering
and pleiotropic effects. In recent years, a correlation between statins and platelet function …
and pleiotropic effects. In recent years, a correlation between statins and platelet function …
[HTML][HTML] Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical …
D Popov - International Journal of Diabetes Mellitus, 2010 - Elsevier
Hyperglycemia, the hallmark of Diabetes mellitus, is a major risk factor for endothelial
dysfunction and vascular complication. In recent years, significant achievements have been …
dysfunction and vascular complication. In recent years, significant achievements have been …
Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow
B Molins, E Pena, R de la Torre… - Cardiovascular …, 2011 - academic.oup.com
Aims We previously reported that C-reactive protein bioactivity on thrombogenesis was
based on loss of its pentameric symmetry, resulting in formation of monomeric C-reactive …
based on loss of its pentameric symmetry, resulting in formation of monomeric C-reactive …
New insights into the role and therapeutic potential of HSP70 in diabetes
AA de Oliveira, VO Mendoza, S Rastogi… - Pharmacological …, 2022 - Elsevier
Emerging evidence indicates that HSP70 represents a key mechanism in the
pathophysiology of β-cell dysfunction, insulin resistance, and various diabetic complications …
pathophysiology of β-cell dysfunction, insulin resistance, and various diabetic complications …
[图书][B] The ESC textbook of intensive and acute cardiovascular care
The ESC Textbook of Intensive and Acute Cardiovascular Care is the official textbook of the
Acute Cardiovascular Care Association (ACVC) of the ESC. Cardiovascular diseases …
Acute Cardiovascular Care Association (ACVC) of the ESC. Cardiovascular diseases …