Pharmacological actions of statins: a critical appraisal in the management of cancer

P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Protein disulfide isomerase in redox cell signaling and homeostasis

FRM Laurindo, LA Pescatore… - Free Radical Biology and …, 2012 - Elsevier
Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …

Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques

R Suades, T Padró, G Vilahur… - Thrombosis and …, 2012 - thieme-connect.com
Plaque rupture followed by thrombosis is the underlying cause of the majority of acute
coronary syndromes. Circulating microparticles (cMPs), membrane blebs released into …

Update on lipids, inflammation and atherothrombosis

L Badimon, RF Storey, G Vilahur - Thrombosis and haemostasis, 2011 - thieme-connect.com
Atherosclerosis is an inflammatory disease that involves the arterial wall and is
characterised by the progressive accumulation of lipids in the vessel wall. The first step is …

Platelet-released extracellular vesicles: the effects of thrombin activation

R Suades, T Padró, G Vilahur, L Badimon - Cellular and Molecular Life …, 2022 - Springer
Platelets exert fundamental roles in thrombosis, inflammation, and angiogenesis,
contributing to different pathologies from cardiovascular diseases to cancer. We previously …

Effect of statins on platelet activation and function: from molecular pathways to clinical effects

A Nenna, F Nappi, M Lusini… - BioMed Research …, 2021 - Wiley Online Library
Purpose. Statins are a class of drugs widely used in clinical practice for their lipid‐lowering
and pleiotropic effects. In recent years, a correlation between statins and platelet function …

[HTML][HTML] Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical …

D Popov - International Journal of Diabetes Mellitus, 2010 - Elsevier
Hyperglycemia, the hallmark of Diabetes mellitus, is a major risk factor for endothelial
dysfunction and vascular complication. In recent years, significant achievements have been …

Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow

B Molins, E Pena, R de la Torre… - Cardiovascular …, 2011 - academic.oup.com
Aims We previously reported that C-reactive protein bioactivity on thrombogenesis was
based on loss of its pentameric symmetry, resulting in formation of monomeric C-reactive …

New insights into the role and therapeutic potential of HSP70 in diabetes

AA de Oliveira, VO Mendoza, S Rastogi… - Pharmacological …, 2022 - Elsevier
Emerging evidence indicates that HSP70 represents a key mechanism in the
pathophysiology of β-cell dysfunction, insulin resistance, and various diabetic complications …

[图书][B] The ESC textbook of intensive and acute cardiovascular care

M Tubaro, P Vranckx, S Price, C Vrints, E Bonnefoy - 2021 - books.google.com
The ESC Textbook of Intensive and Acute Cardiovascular Care is the official textbook of the
Acute Cardiovascular Care Association (ACVC) of the ESC. Cardiovascular diseases …