Pathological self-assembly is a concept that is classically associated with amyloids, such as
amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease. In prokaryotic …

The formation of autoantibodies against chromatin is the main feature of systemic lupus
erythematosis (SLE), an autoimmune disease, which is T-cell dependent and autoantigen …

Macrophage differentiation and polarization is influenced by, and act on, many processes
associated with autoimmunity. However, the molecular mechanisms underlying macrophage …

Objective Some pentraxins, such as C‐reactive protein, bind to apoptotic cells and are
involved in the clearance of these cells. We undertook this study to determine whether …

Background: Serum amyloid P component (SAP) and acute phase proteins like C-reactive
protein contribute to the clearance of apoptotic cells. This response is diminished in systemic …

The maintenance of the levels and correct folding state of proteins (proteostasis) is a
fundamental prerequisite for life. Life has evolved complex mechanisms to maintain …

Objective: To determine the presence of raised titres of anti-serum amyloid P component
(SAP) antibodies in patients with systemic lupus erythematosus (SLE) and to evaluate their …

Background Our previous study revealed that administration of syngeneic female BALB/c
mice with excessive self activated lymphocyte-derived DNA (ALD-DNA) could induce …

Ever since its first discovery in 1957, anti-D NA has taken a special place amongst the other
antinuclear antibodies. Even today, it stands out between these, because of its high …

First-degree relatives (FDRs) and spouses to a population-derived cohort of lupus patients
were investigated for the occurrence of selected autoantibodies and self-reported health …