Abstract Purpose of Review An epidemic of age-associated cognitive decline, most
commonly ascribed to neurodegenerative conditions such as Alzheimer's and Parkinson's …

Autophagy is a catabolic pathway required for the recycling of cytoplasmic materials. To
define the mechanisms underlying autophagy it is critical to quantitatively characterize the …

Finding an effective cure for Alzheimer's disease has eluded scientists despite intense
research. The disease is a cause of suffering for millions of people worldwide and is …

The involvement of iron in the pathogenesis of Alzheimer's disease (AD) may be
multifaceted. Besides potentially inducing oxidative damage, the bioavailability of iron may …

Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play
a key role in several events involved in Alzheimer's disease (AD) pathogenesis. Although …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. The major
pathological changes in AD progression are the generation and accumulation of amyloid …

Background Beyond the signature amyloid-beta plaques and neurofibrillary tangles,
Alzheimer's disease (AD) has been shown to exhibit dysregulated metabolic signaling …

Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by painful
lesions on intertriginous body areas such as the axillary, inguinal, and perianal sites. Given …

Abnormal protein accumulations in the brain are linked to aging and the pathogenesis of
dementia of various types, including Alzheimer's disease. These accumulations can be …

A hallmark of Alzheimer's disease (AD) is the disruption of protein homeostasis
(proteostasis), manifested by the misfolding and aggregation of proteins. Molecular …