The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of
four gynecological types plus breast. Our aims were to identify shared and unique molecular …

The Mediator complex interacts extensively with the RNA polymerase II enzyme and
regulates its ability to express protein-coding genes. The mechanisms by which Mediator …

Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …

Abstract Background Prostate cancer (PCa) cells preferentially metastasize to bone at least
in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription …

Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the
molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism …

Background Functional compartmentalization has emerged as an important factor
modulating the kinetics and specificity of biochemical reactions in the nucleus, including …

Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of
triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can …

The actions of transcriptional coregulators are highly gene-specific, that is, each coregulator
is required only for a subset of the genes regulated by a specific transcription factor. These …