Controlling DNA replication origins in response to DNA damage–inhibit globally, activate locally
M Yekezare, B Gómez-González… - Journal of cell …, 2013 - journals.biologists.com
DNA replication in eukaryotic cells initiates from multiple replication origins that are
distributed throughout the genome. Coordinating the usage of these origins is crucial to …
distributed throughout the genome. Coordinating the usage of these origins is crucial to …
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality
S Alvarez, M Díaz, J Flach, S Rodriguez-Acebes… - Nature …, 2015 - nature.com
Replicative stress during embryonic development influences ageing and predisposition to
disease in adults. A protective mechanism against replicative stress is provided by the …
disease in adults. A protective mechanism against replicative stress is provided by the …
Polε instability drives replication stress, abnormal development, and tumorigenesis
R Bellelli, V Borel, C Logan, J Svendsen, DE Cox… - Molecular cell, 2018 - cell.com
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand
polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε …
polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε …
Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy
During routine genome duplication, many potential replication origins remain inactive or
'dormant'. Such origin dormancy is achieved, in part, by an interaction with the metabolic …
'dormant'. Such origin dormancy is achieved, in part, by an interaction with the metabolic …
Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development
N Shima, KD Pederson - DNA repair, 2017 - Elsevier
DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging
for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands …
for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands …
Comparative Oncogenomics Implicates the Neurofibromin 1 Gene (NF1) as a Breast Cancer Driver
Identifying genomic alterations driving breast cancer is complicated by tumor diversity and
genetic heterogeneity. Relevant mouse models are powerful for untangling this problem …
genetic heterogeneity. Relevant mouse models are powerful for untangling this problem …
Chronic DNA replication stress reduces replicative lifespan of cells by TRP53-dependent, microRNA-assisted MCM2-7 downregulation
Circumstances that compromise efficient DNA replication, such as disruptions to replication
fork progression, cause a state known as DNA replication stress (RS). Whereas normally …
fork progression, cause a state known as DNA replication stress (RS). Whereas normally …
Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells
Abstract The MiniChromosome Maintenance 2-7 (MCM2-7) complex provides essential
replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic …
replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic …
[HTML][HTML] Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context
Abstract Minichromosome maintenance proteins (Mcm2–7) form a hexameric complex that
unwinds DNA ahead of a replicative fork. Deficiency of Mcm proteins leads to replicative …
unwinds DNA ahead of a replicative fork. Deficiency of Mcm proteins leads to replicative …
A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression
SW Luebben, T Kawabata, CS Johnson… - Nucleic acids …, 2014 - academic.oup.com
Accumulating evidence suggests that dormant DNA replication origins play an important role
in the recovery of stalled forks. However, their functional interactions with other fork recovery …
in the recovery of stalled forks. However, their functional interactions with other fork recovery …