Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human
pathogen that results in mucocutaneous lesions in the oral cavity or genital infections …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

Enteroviruses are major causative agents of various human diseases, and some of them are
currently considered to be an enormous threat to public health. However, no effective …

Nucleos (t) ide analogues play pivotal roles as antiviral, cytotoxic or immunosuppressive
agents. Here, we review recent reports of nucleoside analogues that exhibit broad-spectrum …

The concept of a mild mutagen was coined to describe a minor mutagenic activity exhibited
by some nucleoside analogues that potentiated their efficacy as antiretroviral agents. In the …

Resveratrol is a natural phenolic product found in some plants in response to stress and has
been linked to the many health benefits of red wine. Over the past several decades, a great …

Background Human immunodeficiency virus type 2 (HIV-2) is often distinguished clinically
by lower viral loads, reduced transmissibility, and longer asymptomatic periods than for …

Studies of retroviruses have led to many extraordinary discoveries that have advanced our
understanding of not only human diseases, but also molecular biology as a whole. The most …

Human immunodeficiency virus type 2 (HIV-2) infects about two million people worldwide.
HIV-2 has fewer treatment options than HIV-1, yet may evolve drug resistance more quickly …