Adenosine 5′-triphosphate is a well-known extracellular signaling molecule and
neurotransmitter known to activate purinergic P2X receptors. Information has been …

Inflammatory bowel disease (IBD) is a devastating disease that is associated with excessive
inflammation in the intestinal tract in genetically susceptible individuals and potentially …

Evidences show that purinergic signaling is involved in processes associated with health
and disease, including noncommunicable, neurological, and degenerative diseases. These …

Systemic infections by Candida spp. are associated with high mortality rates, partly due to
limitations in current antifungals, highlighting the need for novel drugs and drug targets. The …

Purinergic receptors are ubiquitously expressed throughout the body and they participate in
the autocrine and paracrine regulation of cell function during normal physiological and …

There is abundant evidence that ATP (adenosine 5′-triphosphate) is released from a
variety of cultured cells in response to mechanical stimulation. The release mechanism …

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. The
present study investigated the effects of 50 and 100 mg/kg berberine (BRB) on recognition …

Over expression of nucleotide pyrophosphatase (NPPs) activity is associated with
chondrocalcinosis, osteoarthritis, type 2 diabetes, neurodegenerative diseases, allergies …

Methods: A total of 31 hypertensive group and 28 normotensive (control group) middle-aged
sedentary women were submitted to 6 months of resistance training. All measurements and …

Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release
huge amounts of ATP, which rapidly generates adenosine. Given the nucleoside's putative …