Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Abstract In 1927, Arthur C. Alport first published his description of a triad of symptoms in a
family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A …

Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

The glomerular filtration barrier in the kidney is formed in part by a specialized intercellular
junction known as the slit diaphragm, which connects adjacent actin-based foot processes of …

Cell-lineage–specific transcripts are essential for differentiated tissue function, implicated in
hereditary organ failure, and mediate acquired chronic diseases. However, experimental …

Human genetic and in vivo studies have helped to define the critical importance of
podocytes for kidney function in health and disease. However, as in any other research …

Podocyte dysfunction plays an essential role in the pathogenesis of proteinuria and
glomerulosclerosis. However, the mechanism underlying podocyte dysfunction in many …

NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic
syndrome and low post-transplant recurrence. Background Mutations of NPHS2 are …

Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …