Osteosarcoma (OS) is the most common and aggressive primary malignant type of bone
cancer in children and adolescents. Chemotherapy is one of the most important treatments …

Molecular and non‐invasive imaging are rapidly emerging fields in preclinical cancer drug
discovery. This is driven by the need to develop more efficacious and safer treatments, the …

Pancreatic tumors are the gastrointestinal cancer with the worst prognosis in humans and
with a survival rate of 5% at 5 years. Nowadays, no chemotherapy has demonstrated …

Introduction Repair of large bone defects remains a significant clinical challenge. Bone
marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived …

We recently reported a cationic lipid-based vector of siRNA, termed siRNA lipoplex that was
very efficient in specific gene silencing, both in cell culture and in mouse disease models. To …

Primary cancer cell dissemination is a key event during the metastatic cascade, but context-
specific determinants of this process remain largely undefined. Multiple reports have …

Osteosarcoma is the most common primary malignant tumor of bone, particularly among
children and adolescents. Advances in imaging, surgical techniques, and implants have …

Receptor activator of nuclear factor kappa-B (RANK) and RANK-ligand are relevant targets
for the treatment of polyethylene particle-induced osteolysis. This study assessed the local …

Conventional therapy of primary bone tumors includes surgical excision with wide resection,
which leads to physical and aesthetic defects. For reconstruction of bone and joints …

Osteosarcoma is the most common malignant bone tumor affecting children and
adolescents. Currently, the most common treatment is surgery combined with neoadjuvant …