Prostate cancer is considered a disease of older men (aged> 65 years), but today over 10%
of new diagnoses in the USA occur in young men aged≤ 55 years. Early-onset prostate …

When aberrant, factors critical for organ morphogenesis are also commonly involved in
disease progression. FOXA1 (forkhead box A1), also known as HNF3α (hepatocyte nuclear …

HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR)
activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in …

Prostate gland development is a complex process that involves coordination of multiple
signaling pathways including endocrine, paracrine, autocrine, juxtacrine and transcription …

Prostate morphogenesis occurs in utero in humans and during the perinatal period in
rodents. While largely driven by androgens, there is compelling evidence for a permanent …

Prostate cancer exerts a greater toll on African American men than on White men of
European descent (hereafter referred to as European American men): the disparity in …

The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …

PSGR, a new prostate tissue-specific gene with homology to the G protein-coupled odorant
receptor gene family, has been identified. Here we report the characteristics of the predicted …

The murine prostate is a structure that is made up of four distinct lobes; the dorsal and lateral
prostates (often grouped together as the dorsolateral prostate), the anterior (coagulating …

Dysregulation of HOX gene expression has been implicated as a factor in malignancies for a
number of years. However, no consensus has emerged regarding specific causative genes …