Nectins are immunoglobulin-like cell adhesion molecules (CAMs) that compose a family of
four members. Nectins homophilically and heterophilically interact in trans with each other to …

Over 250 PDZ (PSD95/Dlg/ZO-1) domain-containing proteins have been described in the
human proteome. As many of these possess multiple PDZ domains, the potential …

The small GTPase Rap1 regulates inside-out integrin activation and thereby influences cell
adhesion, migration, and polarity. Several Rap1 effectors have been described to mediate …

Melanoma differentiation associated gene-9 (MDA-9), also known as syntenin, functions as
a positive regulator of melanoma progression and metastasis. In contrast, the Raf kinase …

Abstract Afadin/AF6, an F-actin-binding protein, is ubiquitously expressed in epithelia and
has a key role during development, through its regulatory role in cell–cell junction …

Abstract A rare location, t (6; 11)(q27; q23)(MLL-AF6), is associated with poor outcome in
childhood acute myeloid leukemia (AML). The described mechanism by which MLL-AF6 …

Cell movement is a complex and dynamic process that causes changes in cell morphology
by reorganizing the actin cytoskeleton and modulating cell adhesions. For directional cell …

Cell signaling pathways are essentially organized through the distribution of various types of
binding domains in signaling proteins, with each domain binding to specific target …

Regulation of axon growth, guidance, and branching is essential for constructing a correct
neuronal network. R-Ras, a Ras-family small GTPase, has essential roles in axon formation …

Adherens (AJ) and tight junctions (TJ) maintain cell‐cell adhesions and cellular polarity in
normal tissues. Afadin, a multi‐domain scaffold protein, is commonly found in both adherens …