Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

MiRNAs are small non-coding RNAs that interact with their target mRNAs for
posttranscriptional gene regulation. Finely controlled miRNA biogenesis, target recognition …

Neurodevelopment is a highly regulated process that relies on the precise regulation of
gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the …

ATR-X, an acronym for alpha thalassemia and mental retardation X-linked, syndrome is a
congenital condition predominantly affecting males, characterized by mild to severe …

To achieve replicative immortality, cancer cells must activate telomere maintenance
mechanisms to prevent telomere shortening.~ 85% of cancers circumvent telomeric attrition …

ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA
damage repair and heterochromatin maintenance. It has been widely studied for its role in …

FOXG1 syndrome is a developmental encephalopathy caused by FOXG1 (Forkhead box
G1) mutations, resulting in high phenotypic variability. However, the upstream transcriptional …

Chromatin dysregulation has emerged as a major hallmark of neurodevelopmental
disorders such as intellectual disability (ID) and autism spectrum disorders (ASD). The …

Abstract α‐Thalassemia X‐linked intellectual disability (ATR‐X) syndrome is a
neurodevelopmental disorder caused by mutations in the ATRX gene that encodes a SNF2 …

The PHF6 mutation c. 1024C> T; p. R342X, is a recurrent cause of Börjeson–Forssman–
Lehmann Syndrome (BFLS), a neurodevelopmental disorder characterized by moderate …