The Flaviviridae virus family consists of the genera Hepacivirus, Pestivirus, and Flavivirus,
with approximately 70 viral types that use arthropods as vectors. Among these diseases …

Structural genomics involves the advent of three-dimensional structures of the genome
encoded proteins through various techniques available. Numerous structural genomics …

A series of cyclic active‐site‐directed inhibitors of the NS2B‐NS3 proteases from Zika
(ZIKV), West Nile (WNV), and dengue‐4 (DENV4) viruses has been designed. The most …

In this study, we utilized human DNA topoisomerase IIα as a model target to outline a
dynophore-based approach to catalytic inhibitor design. Based on MD simulations of a …

Zika virus (ZIKV), which is associated with severe diseases in humans, has spread rapidly
and globally since its emergence. ZIKV and dengue virus (DENV) are closely related, and …

The flavivirus genus of the Flaviviridae family comprises Dengue, Zika and West-Nile viruses
which constitute unmet medical needs as neither appropriate antivirals nor safe vaccines …

West Nile virus infections can cause severe neurological symptoms. During the last 25
years, cases have been reported in Asia, North America, Africa, Europe and Australia …

The Zika virus (ZIKV) remains a potential threat to the public health due to the lack of both an
approved vaccination or a specific treatment. In this work, a series of peptidic inhibitors of the …

Viral proteases have been established as drug targets in several viral diseases including
human immunodeficiency virus and hepatitis C virus infections due to the essential role of …

Dengue virus is an important class of virus of the Flavivirus family that is accountable for the
major cause of dengue fever, which could progress to dengue shock syndrome (DSS) which …