T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …

Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …

The scarcity of malignant Hodgkin and Reed–Sternberg cells hampers tissue-based
comprehensive genomic profiling of classic Hodgkin lymphoma (cHL). By contrast, liquid …

Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …

Background Endogenous or iatrogenic antitumour immune responses can improve the
course of follicular lymphoma, but might be diminished by immune checkpoints in the tumour …

This multicenter phase I/II clinical trial evaluated intratumoral SD-101, a TLR9 agonist, and
low-dose radiation in patients with untreated indolent lymphoma. Twenty-nine enrolled …

Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells
undergo somatic mutation and selection and eventual differentiation into memory B cells or …

All cases of multiple myeloma (MM) are preceded by precursor states termed monoclonal
gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). Genetic …

Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the
Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical …

Heterogeneity in the tumor microenvironment (TME) of follicular lymphomas (FLs) can affect
clinical outcomes. Current immunotherapeutic strategies, including antibody-and cell-based …