In the lungs, macrophages constitute the first line of defense against pathogens and foreign
bodies and play a fundamental role in maintaining tissue homeostasis. Activated …

The overlapping metabolic reprogramming of cancer and immune cells is a putative
determinant of the antitumor immune response in cancer. Increased evidence suggests that …

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …

Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it
secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As …

Beyond hemostasis, platelets actively participate in immune cell recruitment and host
defense, yet their potential in the resolution of inflammatory processes remains unknown …

Lung macrophages constitute the first line of defense against airborne particles and
microbes and are key to maintaining pulmonary immune homeostasis. There is increasing …

Lipid metabolism plays an important role in many lung functions. Disorders of lipid
metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD) …

COPD is driven by exogenous and endogenous oxidative stress derived from inhaled
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …

Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global
mortality, with three million deaths reported annually. This impact is expected to increase …

Asthma is a highly heterogeneous disease, but the pathogenesis of asthma is still unclear. It
is well known that the airway inflammatory immune response is the pathological basis of …