There are different types of nutritionally mediated oxidative stress sources that trigger
inflammation. Much information indicates that high intakes of macronutrients can promote …

Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …

A hallmark of type 2 diabetes mellitus (T2DM) is the development of pancreatic β cell failure,
which results in insulinopenia and hyperglycemia. We show that the adipokine adipsin has a …

Metabolic derangement with poor glycemic control accompanying overweight and obesity is
associated with chronic low-grade inflammation and hyperinsulinemia. Macrophages, which …

The inflammasome is a protein complex composed of a variety of proteins in cells and which
participates in the innate immune response of the body. It can be activated by upstream …

The bile acid–responsive G protein–coupled receptor TGR5 is involved in several metabolic
processes, and recent studies suggest that TGR5 activation may promote pathways that are …

With the awareness that immune-inflammatory cross-talk is at the heart of many disorders,
the desire for novel immunomodulatory strategies in the therapy of such diseases has grown …

Summary Uncoupling protein 1 (UCP1) is a major regulator of brown and beige adipocyte
energy expenditure and metabolic homeostasis. However, the widely employed UCP1 loss …

Obesity as part of metabolic syndrome is a major lifestyle disorder throughout the world.
Current drug treatments for obesity produce small and usually unsustainable decreases in …

The impact of complement on cancer metastasis has not been well studied. In this report, we
demonstrate in a preclinical mouse model of breast cancer that the complement …