BCMA-targeted immunotherapy for multiple myeloma
B Yu, T Jiang, D Liu - Journal of hematology & oncology, 2020 - Springer
B cell maturation antigen (BCMA) is a novel treatment target for multiple myeloma (MM) due
to its highly selective expression in malignant plasma cells (PCs). Multiple BCMA-targeted …
to its highly selective expression in malignant plasma cells (PCs). Multiple BCMA-targeted …
Targeting B cell maturation antigen (BCMA) in multiple myeloma: potential uses of BCMA-based immunotherapy
SF Cho, KC Anderson, YT Tai - Frontiers in immunology, 2018 - frontiersin.org
The approval of the first two monoclonal antibodies targeting CD38 (daratumumab) and
SLAMF7 (elotuzumab) in late 2015 for treating relapsed and refractory multiple myeloma …
SLAMF7 (elotuzumab) in late 2015 for treating relapsed and refractory multiple myeloma …
Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma
B-cell maturation antigen (BCMA), highly expressed on malignant plasma cells in human
multiple myeloma (MM), has not been effectively targeted with therapeutic monoclonal …
multiple myeloma (MM), has not been effectively targeted with therapeutic monoclonal …
De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease
Background IgG 4-related disease (IgG 4-RD) is a poorly understood, multiorgan, chronic
inflammatory disease characterized by tumefactive lesions, storiform fibrosis, obliterative …
inflammatory disease characterized by tumefactive lesions, storiform fibrosis, obliterative …
Antibody–drug conjugates as novel anti-cancer chemotherapeutics
C Peters, S Brown - Bioscience reports, 2015 - portlandpress.com
Over the past couple of decades, antibody–drug conjugates (ADCs) have revolutionized the
field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues …
field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues …
Antibody–drug conjugates: targeted drug delivery for cancer
SC Alley, NM Okeley, PD Senter - Current opinion in chemical biology, 2010 - Elsevier
The antibody–drug conjugate field has made significant progress recently owing to careful
optimization of several parameters, including mAb specificity, drug potency, linker …
optimization of several parameters, including mAb specificity, drug potency, linker …
Targeting B-cell maturation antigen in multiple myeloma
YT Tai, KC Anderson - Immunotherapy, 2015 - Taylor & Francis
Novel effective immunotherapies are needed for patients with multiple myeloma (MM), since
disease recurrence remains a major obstacle. B-cell maturation antigen (BCMA), a cell …
disease recurrence remains a major obstacle. B-cell maturation antigen (BCMA), a cell …
Potent antibody drug conjugates for cancer therapy
PD Senter - Current opinion in chemical biology, 2009 - Elsevier
Significant progress has been made in the past few years in the area of antibody drug
conjugates (ADCs) for the selective delivery of cytotoxic drugs to tumors. Early work in this …
conjugates (ADCs) for the selective delivery of cytotoxic drugs to tumors. Early work in this …
Serum B‐cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival
E Sanchez, M Li, A Kitto, J Li, CS Wang… - British journal of …, 2012 - Wiley Online Library
Although TNFRSF 17 (also designated as B‐cell maturation antigen (BCMA)) is expressed
on tumour cells in B‐cell malignancies, it has not been found in serum. The present study …
on tumour cells in B‐cell malignancies, it has not been found in serum. The present study …
An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma
L Lee, B Draper, N Chaplin, B Philip… - Blood, The Journal …, 2018 - ashpublications.org
B-cell maturation antigen (BCMA) is a promising therapeutic target for multiple myeloma
(MM), but expression is variable, and early reports of BCMA targeting chimeric antigen …
(MM), but expression is variable, and early reports of BCMA targeting chimeric antigen …