Breast cancer is the most prevalent type of tumor and the second leading cause of death
due to cancer among women. Although screening methods, diagnosis and therapeutic …

Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …

Resistance to platinum-based chemotherapy is a major clinical challenge in ovarian cancer,
contributing to the high mortality-to-incidence ratio. Management of the platinum-resistant …

Drug pharmacokinetics is influenced by the function of metabolising enzymes and
influx/efflux transporters. Genetic variability of these genes is known to impact on clinical …

Metabolic reprogramming is a common hallmark of cancer cells. Cancer cells exhibit
metabolic flexibility to maintain high proliferation and survival rates. In other words …

Anthracyclines such as daunorubicin are anticancer agents that are transported into cells
and exert cytotoxicity by blocking DNA metabolism. Although there is evidence for active …

Metabolic flexibility is a peculiar hallmark of cancer cells. A growing number of observations
reveal that tumors can utilize a wide range of substrates to sustain cell survival and …

Cisplatin [cis-diamminedichloroplatinum (II)] is a platinum-based anticancer drug widely
used for the treatment of various cancers. It forms interstrand and intrastrand cross-linking …

Oxaliplatin is important for the clinical treatment of colorectal cancer and other
gastrointestinal malignancies, but tumour resistance is limiting. Several oxaliplatin …

Introduction. Membrane transporters are integral to the maintenance of cellular integrity of all
tissue and cell types. While transporters play an established role in the systemic …