Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …

Striosomes form neurochemically specialized compartments of the striatum embedded in a
large matrix made up of modules called matrisomes. Striosome-matrix architecture is …

The striatum is a heterogeneous structure with a diverse range of neuron types and
neuromodulators. Three decades of anatomical and biochemical studies have established …

The dopamine systems of the brain powerfully influence movement and motivation. We
demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet …

Monoamine neurotransmitters (MNTs) belong to one of the most important groups of
neurotransmitters in the central nervous system. They play crucial role in functioning of …

Pathophysiological damages and loss of function of dopamine neurons precede their
demise and contribute to the early phases of Parkinson's disease. The presence of aberrant …

Highlights•Hebbian protocols induce bidirectional plasticity (LTP and LTD) in the
striatum.•Multiple pathways interact to induce activity-dependent STDP in the …

The striatum plays a central role in guiding numerous complex behaviors, ranging from
motor control to action selection and reward learning. The diverse responsibilities of the …

The circuitry of the striatum is characterized by two organizational plans: the division into
striosome and matrix compartments, thought to mediate evaluation and action, and the direct …

Striosomes were discovered several decades ago as neurochemically identified zones in
the striatum, yet technical hurdles have hampered the study of the functions of these striatal …