Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation
BJ Drew, MJ Ackerman, M Funk, WB Gibler, P Kligfield… - Circulation, 2010 - Am Heart Assoc
however, this characteristic twisting morphology may not be evident in all ECG leads.
Second, episodes of drug-induced TdP usually start with a short-long-short pattern of RR …
Second, episodes of drug-induced TdP usually start with a short-long-short pattern of RR …
The measurement of the QT interval
PG Postema, A AM Wilde - Current cardiology reviews, 2014 - ingentaconnect.com
The evaluation of every electrocardiogram should also include an effort to interpret the QT
interval to assess the risk of malignant arrhythmias and sudden death associated with an …
interval to assess the risk of malignant arrhythmias and sudden death associated with an …
QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the …
This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat
QT interval variability (QTV) on surface electrocardiograms. The text covers measurement …
QT interval variability (QTV) on surface electrocardiograms. The text covers measurement …
The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias
The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …
intended to be of practical value in the investigation of experimental arrhythmias induced by …
Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine
L Belardinelli, JC Shryock, H Fraser - Heart, 2006 - heart.bmj.com
Pathological conditions linked to imbalances in oxygen supply and demand (for example,
ischaemia, hypoxia and heart failure) are associated with disruptions in intracellular sodium …
ischaemia, hypoxia and heart failure) are associated with disruptions in intracellular sodium …
Drug‐induced torsades de pointes and implications for drug development
RR Fenichel, M Malik, C Antzelevitch… - Journal of …, 2004 - Wiley Online Library
Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an
adverse effect of pharmacotherapy. Recently developed understanding of the underlying …
adverse effect of pharmacotherapy. Recently developed understanding of the underlying …
Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms
G Frommeyer, L Eckardt - Nature Reviews Cardiology, 2016 - nature.com
Drug-induced ventricular tachyarrhythmias can be caused by cardiovascular drugs,
noncardiovascular drugs, and even nonprescription agents. They can result in arrhythmic …
noncardiovascular drugs, and even nonprescription agents. They can result in arrhythmic …
System for processing physiological data
M Brockway, B Brockway - US Patent 9,339,202, 2016 - Google Patents
Physiological signals such as ECG signals are obtained from a patient. In accordance with
one or more embodiments, an apparatus, system and/or method is directed to at least two …
one or more embodiments, an apparatus, system and/or method is directed to at least two …
Cardiac ventricular repolarization reserve: a principle for understanding drug‐related proarrhythmic risk
Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …
cardiac compounds and may lead to the development of life‐threatening Torsades de …
Drug-induced inhibition and trafficking disruption of ion channels: pathogenesis of QT abnormalities and drug-induced fatal arrhythmias
LX Cubeddu - Current cardiology reviews, 2016 - ingentaconnect.com
Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is
increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced …
increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced …