Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation

BJ Drew, MJ Ackerman, M Funk, WB Gibler, P Kligfield… - Circulation, 2010 - Am Heart Assoc
however, this characteristic twisting morphology may not be evident in all ECG leads.
Second, episodes of drug-induced TdP usually start with a short-long-short pattern of RR …

The measurement of the QT interval

PG Postema, A AM Wilde - Current cardiology reviews, 2014 - ingentaconnect.com
The evaluation of every electrocardiogram should also include an effort to interpret the QT
interval to assess the risk of malignant arrhythmias and sudden death associated with an …

QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the …

M Baumert, A Porta, MA Vos, M Malik, JP Couderc… - Europace, 2016 - academic.oup.com
This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat
QT interval variability (QTV) on surface electrocardiograms. The text covers measurement …

The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias

MJ Curtis, JC Hancox, A Farkas, CL Wainwright… - Pharmacology & …, 2013 - Elsevier
The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine

L Belardinelli, JC Shryock, H Fraser - Heart, 2006 - heart.bmj.com
Pathological conditions linked to imbalances in oxygen supply and demand (for example,
ischaemia, hypoxia and heart failure) are associated with disruptions in intracellular sodium …

Drug‐induced torsades de pointes and implications for drug development

RR Fenichel, M Malik, C Antzelevitch… - Journal of …, 2004 - Wiley Online Library
Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an
adverse effect of pharmacotherapy. Recently developed understanding of the underlying …

Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms

G Frommeyer, L Eckardt - Nature Reviews Cardiology, 2016 - nature.com
Drug-induced ventricular tachyarrhythmias can be caused by cardiovascular drugs,
noncardiovascular drugs, and even nonprescription agents. They can result in arrhythmic …

System for processing physiological data

M Brockway, B Brockway - US Patent 9,339,202, 2016 - Google Patents
Physiological signals such as ECG signals are obtained from a patient. In accordance with
one or more embodiments, an apparatus, system and/or method is directed to at least two …

Cardiac ventricular repolarization reserve: a principle for understanding drug‐related proarrhythmic risk

A Varró, I Baczkó - British journal of pharmacology, 2011 - Wiley Online Library
Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …

Drug-induced inhibition and trafficking disruption of ion channels: pathogenesis of QT abnormalities and drug-induced fatal arrhythmias

LX Cubeddu - Current cardiology reviews, 2016 - ingentaconnect.com
Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is
increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced …