The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …

Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …

The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Therapeutic targeting of the processes that regulate histone modification is a growing area
of scientific exploration. Although most interest has concentrated on the various families of …

Epilepsy is a common episodic neurological disorder or condition characterized by recurrent
epileptic seizures, and genetics seems to play a key role in its etiology. Early linkage studies …

Over 60 bromodomains belonging to proteins with very different functions have been
identified in humans. Several of them interact with acetylated lysine residues, leading to the …

The bromodomains and extra-terminal domain (BET) family proteins recognize acetylated
chromatin through their bromodomains (BDs) and help in regulating gene expression. BDs …

Autism spectrum disorder (ASD) is over four times more prevalent in males compared to
females. Increased understanding of sex differences in ASD endophenotypes could add …

Cancer and inflammation are strongly interconnected processes. Chronic inflammatory
pathologies can be at the heart of tumor development; similarly, tumor-elicited inflammation …

KCC2 is a vital neuronal K+/Cl− cotransporter that is implicated in the etiology of numerous
neurological diseases. In normal cells, KCC2 undergoes developmental dephosphorylation …