In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a
prion (designated PrP Sc). The normal cellular prion protein (PrP C) is encoded by an …

The definite diagnosis of human sporadic Creutzfeldt–Jakob disease (sCJD) largely
depends on postmortem neuropathology and PrPSc detection in the brain. The development …

Neurodegenerative protein misfolding diseases impact tens of millions of people worldwide,
contributing to millions of deaths and economic hardships across multiple scales. The …

The circadian rhythm of the human brain is attuned to sleep-wake cycles that entail global
alterations in neuronal excitability. This periodicity involves a highly coordinated regulation …

The seeding activity of prions has been exploited for the development of ultrasensitive
assays for prion diseases. Among the more practical are Real-Time Quaking Induced …

Motivation Fluorophore-assisted seed amplification assays (F-SAAs), such as real-time
quaking-induced conversion (RT-QuIC) and fluorophore-assisted protein misfolding cyclic …

Diagnostic tools for the detection of protein-misfolding diseases (ie, proteopathies) are
limited. Gold nanoparticles (AuNPs) facilitate sensitive diagnostic techniques via visual color …

Chronic wasting disease (CWD) is a disease affecting cervids and is caused by prions
accumulating as pathogenic fibrils in lymphoid tissue and the central nervous system …

(RT-QuIC)(2–4), to aid in antemortem diagnosis of sporadic Creutzfeldt-Jakob disease
(sCJD). In both QuIC reactions, the presence of minute amounts of misfolded prion protein …

Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the
performance characteristics of three ante-mortem tests commonly used to support diagnoses …