Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

The extracellular domain of plasma membrane integrin αvβ3 contains a cell surface receptor
for thyroid hormone analogues. The receptor is largely expressed and activated in tumor …

Integrins require an activation step prior to ligand binding and signaling. How talin and
kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we …

Kindlins and talins are integrin-binding proteins that are critically involved in integrin
activation, an essential process for many fundamental cellular activities including cell-matrix …

Highlights•Targeting the ectodomain of αvβ3 integrin can control tumour blood vessel
development.•Facing the problems of targeting the integrin ectodomain.•Thinking about …

Reduced levels of kindlin-2 (K2) in endothelial cells derived from K2+/− mice or C2C12
myoblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton …

Integrins mediate cell adhesion to extracellular matrix and transduce signals bidirectionally
across the membrane. Integrin α V β 3 has been shown to play an essential role in tumor …

Platelet receptors are how platelets interact with their environment in order to function. They
enable signals to pass to the platelet interior and change functional aspects of the platelet …

Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived circulating
signaling molecule that has been implicated in chronic kidney disease, such as focal …

Increasing evidence has suggested a critical role for endothelial‐to‐mesenchymal transition
(EndoMT) in a variety of pathological conditions. MicroRNA‐200c‐3p (miR‐200c‐3p) has …