Therapeutic pipeline in nonalcoholic steatohepatitis

R Vuppalanchi, M Noureddin, N Alkhouri… - Nature Reviews …, 2021 - nature.com
Our understanding of nonalcoholic fatty liver disease pathophysiology continues to advance
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …

Complications, morbidity and mortality of nonalcoholic fatty liver disease

A Mantovani, E Scorletti, A Mosca, A Alisi, CD Byrne… - Metabolism, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized public health
problem, affecting up to a quarter of the world's adult population. The burden of NAFLD is …

The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease

M Eslam, SK Sarin, VWS Wong, JG Fan… - Hepatology …, 2020 - Springer
Metabolic associated fatty liver disease (MAFLD) is the principal worldwide cause of liver
disease and affects nearly a quarter of the global population. The objective of this work was …

Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: results from randomized phase III STELLAR trials

SA Harrison, VWS Wong, T Okanoue, N Bzowej… - Journal of …, 2020 - Elsevier
Background & Aims Apoptosis signal-regulating kinase 1 (ASK1) plays a key role in
hepatocyte injury, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH). We …

Geographical similarity and differences in the burden and genetic predisposition of NAFLD

TCF Yip, E Vilar‐Gomez, S Petta, Y Yilmaz… - Hepatology, 2023 - journals.lww.com
NAFLD has become a major public health problem for more than 2 decades with a growing
prevalence in parallel with the epidemic of obesity and type 2 diabetes (T2D). The disease …

Nonalcoholic fatty liver disease burden: Australia, 2019–2030

LA Adams, SK Roberts, SI Strasser… - Journal of …, 2020 - Wiley Online Library
Abstract Background and Aim Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic
steatohepatitis (NASH) account for a large and growing proportion of liver disease burden …

The epidemiology of NAFLD in Mainland China with analysis by adjusted gross regional domestic product: a meta-analysis

Y Wu, QI Zheng, B Zou, YH Yeo, X Li, J Li, X Xie… - Hepatology …, 2020 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver
disease worldwide. This study aimed to estimate the prevalence, incidence, and outcome of …

Estimating global prevalence, incidence, and outcomes of non-alcoholic fatty liver disease from 2000 to 2021: systematic review and meta-analysis

J Liu, Y Tian, X Fu, C Mu, M Yao, Y Ni, Y Liu… - Chinese Medical …, 2022 - mednexus.org
Background: The increasing burden of non-alcoholic fatty liver disease (NAFLD) worldwide
imposes an emerging public health issue. We perform the current study to estimate the …

[HTML][HTML] Metabolic associated fatty liver disease: Addressing a new era in liver transplantation

MG Gill, A Majumdar - World journal of hepatology, 2020 - ncbi.nlm.nih.gov
Metabolic associated fatty liver disease (MAFLD), previously termed non-alcoholic fatty liver
disease, is the leading global cause of liver disease and is fast becoming the most common …

The effect of diet and exercise interventions on body composition in liver cirrhosis: a systematic review

HE Johnston, TG Takefala, JT Kelly, SE Keating… - Nutrients, 2022 - mdpi.com
Alterations in body composition, in particular sarcopenia and sarcopenic obesity, are
complications of liver cirrhosis associated with adverse outcomes. This systematic review …